Round 2

Round 1 finished with 700+ designs submitted and 200 of them being tested through Adaptyv Bio’s lab. Use the newly generated data and evaluate on a retrospective benchmark to inform your designs ahead of your submission for Round 2. Same target, more data, who will win?
Dataset

biogen/adme-fang-v1

Molecule

adme

Size: 3,521

384 KB

7 benchmarks

2024-07-10
Benchmarks

polaris/drewry2017-pkis2-subset-v2

Molecule

adme

Size: 3,521

384 KB

7 benchmarks

2024-07-10

EGFR

Organism HUMAN

Accession ID P00533

Epidermal Growth Factor Receptor (EGFR) is a transmembrane protein that plays a critical role in cell growth, differentiation, and survival. It is frequently overexpressed or mutated in various cancers, including non-small cell lung cancer, colorectal cancer, and head and neck cancer. This makes EGFR a crucial target for cancer therapies such as Cetuximab, an antibody with more than 1B USD in annual revenue.

Sequence

Copy View PDB
LEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKII

Prizes

In partnership with the AIDrugX Workshop at NeurIPS 2024, the top designer will be given a 15-minute presentation slot to describe their design approach.

1st Place

Speaking slot at NeurIPS + $5K cash

2nd Place

$3K cash

3rd Place

$1K cash

In addition, the top 5 designers with the best binding affinity (= lowest KD value) will receive 10 free assays each to run at Adaptyv Bio for their own protein design campaigns.

Top 10 designers will additionally receive an Adaptyv Bio & Polaris Merch Pack